Hemangioma infantil congênito: opção de tratamento homeopático com medicamento calcárea carbônica / Congenital infantile hemangioma: homeopathic treatment option with carbonic limestone medicine

Este é o relato de um caso clínico de uma criança lactente que a desde o nascimento possui uma tumefação de coloração vermelho-rubro na região occipital direita e outra na região infra escapular próxima a axila ipsilateral, de relevo e bordas irregulares. À avaliação médica, ficou com diagnóstico de hemangioma infantil. O hemangioma infantil é um tumor vascular benigno comum, representando a anomalia vascular mais frequentemente encontrada em idade pediátrica. O objetivo deste trabalho foi mostrar a ação do tratamento homeopático com a medicação Calcárea Carbônica como opção terapêutica com boa eficácia para o tratamento do hemangioma infantil.

The present document outlines the clinical case of an infant child who, since birth, has a reddish-red swelling in the right occipital region and another in the infrascapular area close to the ipsilateral armpit, with relief and irregular edges. Upon medical evaluation, she was diagnosed with infantile hemangioma. Infantile hemangioma is a common benign vascular tumour, representing the vascular anomaly most frequently found in children. This work aimed to show the action of homeopathic treatment with Calcárea Carbonica as a therapeutic option with good efficacy for the treatment of infantile hemangioma.

Management of early years of simple and mucopurulent chronic bronchitis with pre-defined Homoeopathic medicines ­ a Prospective Observational Study with 2-Years Follow-Up

Background Simple and mucopurulent chronic bronchitis (SMCB) is characterized by recurrent mucoid or mucopurulent expectoration in absence of localized suppurative disease. This observational open label study was undertaken to evaluate the effects of homeopathic medicine in SMCB. Methods 1902 patients were screened from 07 centres out of which 1305 were excluded. 597 patients were enrolled as per the inclusion and exclusion criteria. A total of 14 pre-defined homeopathic medicines were shortlisted for prescription after repertorizing the pathological symptoms of SMCB. Outcomes were assessed through chronic bronchitis symptom scale (CBSS) and FEV1/ FVC ratio with spirometry for over a period of two years. Appearance of any change (relief/ worse)/ status quo was immediately followed by placebo/ change in dilution/ change in remedy. Statistical analysis was done using SPSS version 20. Results: 532 patients were analyzed based on the intention to treat principle using last observation carry forward method. Mean CBS score reduced from 29.86±4.5 at baseline to 12.33±7.6 at completion of 2 years. Repeated measures ANOVA, at time points 0 (baseline), 3, 6, 9, 12 ,15, 18, 21 and 24 months, showed significant reduction in CBS scores [Wilk's Lambda 0.104, F=564, df 524; p=00001]. The FEV1 and FEV1/FVC was maintained within normal limits. 86% prescriptions included Lycopodium, Arsenicum album, Pulsatilla, Phosphorus, Stannum metallicum, Calcarea carbonica, Silicea, Bryonia alba. Conclusion: The result suggests effectiveness of homeopathic treatment in early years of SCMB patients. Controlled trials are warranted. (AU)

Tratamento homeopático eugênico na gestação tardia / Eugenic homeopathic treatment in late gestation

O objetivo do presente trabalho é relatar um caso clínico de paciente primigesta sendo a gestação tardia, através de método de fertilização in vitro e com insucesso na primeira tentativa do procedimento devido a aborto após a mesma, buscou o tratamento homeopático para prepará-la para um segundo procedimento e para obter uma gestação eugênica. Optou em buscar a homeopatia médica como auxílio para a adequada formação fetal, e acompanhamento homeopático durante a gestação, fez uso dos medicamentos homeopáticos na gestação desde o primeiro trimestre ao último trimestre e até ao parto, com supervisão multidisciplinar pelo médico homeopata, médico ginecologista especializado em infertilidade no primeiro momento e após pelo ginecologista ­ obstetra para o pré-natal. A paciente apresentava sintomas de tristeza após perda do concepto na primeira fertilização in vitro, indecisão, medo de ser mãe, indiferença afetiva, intolerância á contradições, e extrema aversão e irritabilidade ao consolo do marido, sentindo- se culpada e vazia após o aborto. Metodologia: A paciente foi acompanhada em consultório particular durante 12 meses, foram realizadas três consultas e três retornos em que foi avaliada subjetivamente e clinicamente concomitante o pré-natal obstétrico. Obteve êxito na segunda fertilização in-vitro, foi prescrito Sépia succus (Potências progressivas 30 CH, 200 CH, 1 M/FC, 10 M/FC, 50 M/FC), Calcárea carbônica 12 CH ás segundas- feiras, Calcárea phosphórica 12 CH ás quartas-feiras, Calcárea fluorica 12 CH ás sextas- feiras, Psorinum 200 CH dose única no primeiro trimestre, Medorrhinum 200 CH no segundo trimestre em dose única, Luesinum 200 CH dose única no terceiro trimestre, e quinze dias antes do parto foi medicada com Caulophyllum thalictroides 12 CH e Cimicífuga racemosa 12 CH duas vezes por semana. Resultados: Nos primeiros parâmetros observamos a melhora gradativa do humor, conforme o aumento das potências do medicamento homeopático Sépia succus, até a melhora da aceitação da gravidez com sentimentos de autoconfiança em ser uma boa mãe, mais paciente com o marido, melhora geral do seu quadro de tristeza e indiferença afetiva aos familiares, melhora do sono e ausência dos transtornos por sonhos desagradáveis do inicio, também relatou durante a gestação aversão a doces, sem queixas de travar os dentes que apresentava anteriormente, clinicamente manteve-se hemodinamicamente estável, sem edemas, mantendo ganho de peso proporcional a idade gestacional, níveis pressóricos arteriais adequados, níveis glicêmicos normais, ausência de infecções urinárias na gestação, ganho de peso e crescimento fetal compatíveis, movimentos fetais adequados durante os exames de ultra-som gestacional e sentidos pela paciente que após o tratamento acariciava constantemente a barriga, apresentava comportamento carinhoso observado durante toda a consulta homeopática. Os resultados obtidos mostraram sucesso no tratamento homeopático durante toda a gestação, o que sugere através das matérias médicas e experimentação em homem são, que o medicamento homeopático trouxe sensação subjetiva de bem estar geral, a paciente evoluiu sem depressão pós-parto, foi realizado parto cesárea devido a idade avançada da parturiente e início de aumento dos níveis de pressão arterial ao final da gestação, também a paciente compareceu a consulta em perfeito estado clínico até a véspera do parto. (AU)

Increase in growth of eucalyptus seedlings with application of homeopathic preparations

The use of less impacting techniques in agricultural systems is the global trend, so the use of homeopathic preparations on these systems has been studied as ecologically sound technology. This study had the object to study the interaction between the homeopathic preparations and the development of Eucalyptus urophylla S. T. Blake seedlings and was conducted from May 2007 to July 2007, in the greenhouse of the Department of Plant Science at the Federal University of Viçosa, MG, Brazil. Applications were made in one-day intervals and preparations utilized were Phosphorus, Calcarea carbonica, Kali muriaticum, Magnesia carbonica, all in potencies 3CH and 12CH and the controls were water and alcohol 3CH. Parameters of seedlings quality were measured in different times during the experiment, up to the end. Kali muriaticum 12CH promoted increased root length of approximately 55% compared to the water control. Phosphorus 3CH differed from other treatments considering the total green mass. The homeopathic preparations Phosphorus 3CH and Kali muriaticum 12CH increased the root growth, in relation to controls. The responses obtained with the application of Phosphorus 3CH indicate the viability of its agronomic use to increase of the root capacity of absorbing elements, as much as necessary for the plant growth. (AU)

Calcarea Carbonica Ostrearum para la obesidad en adolescentes mexicanos / Calcarea Carbonica Ostrearum for mexican adolescent obesity

Antecedentes: la obesidad es un problema de salud pública en México que va en aumento en niños y adolescentes, incrementando el riesgo de enfermedades cardiovasculares y metabólicas a temprana edad. Tradicionalmente, en la práctica clínica homeopática, Calcarea carbonica ostrearum se ha utilizado para la obesidad; sin embargo, no existen estudios de calidad metodológica donde se demuestre sueficacia. El objetivo del estudio fue demostrar la eficacia de Calcarea carbonica ostrearum vs placebo para disminuir la obesidad en adolescentes. Material y métodos: se realizó un ensayo clínico controlado, aleatorizado, doble ciego, de 15 semanas de duración en el Hospital General de México (Ciudad de México) de febrero a agosto de 2010, en el que se incluyó a 25 pacientes adolescentesobesos de entre 14 y 18 años de edad. Se les administró Calcarea carbonica ostrearum 30CH, o placebo, junto con cambios en la dieta y ejercicio. Las variables medidas fueron: peso, índice de masa corporal, perímetro abdominal y porcentaje de grasa corporal. Resultados: se encontraron diferencias estadísticamente significativas entre Calcarea carbonica ostrearum 30CH y placebo en el porcentaje de grasa corporal (Calcarea carbonica ostrearum 2.9±1.1 vs placebo 1.3±1.5; diferencia=1.63, p<0.05). En las demás variables (peso, índice de masa corporal y perímetro abdominal) no se encontraron diferencias estadísticamente significativas entre grupos después de 15 semanas de tratamiento. Conclusión: Calcarea carbonica ostrearum 30CH puede ser efectiva para reducir el porcentaje de grasa corporal en adolescentes obesos. Es necesario que se realicen ensayos clínicos controlados con tamaños de muestra más grandes para corroborar estos resultados. (AU)

Background: obesity is a health problem in Mexico. The prevalence of juvenile and child obesity is raising and is strongly related to cardiovascular and metabolic risk factors. Traditionally, in daily homeopathic practice, Calcarea carbonica ostrearum is prescribed for obesity. Nevertheless there is a lack of well-designed studies to prove its efficacy. The objetive of this study was to investigate the efficacy of Calcarea carbonica ostrearum 30CH vs placebo for reducing obesity in adolescents. Methods/design: a randomized, double-blind, placebo-controlled two-arm trial with a 15 weeks follow-up study was conducted in the Hospital General de Mexico in Mexico City. Twenty-five adolescents between 14 and 18 years were included. The outcomes were: weight, body mass index, abdominal circumference and percentage of body fat. Results: percentage of body fat was the only outcome with statistically significant difference between Calcarea carbonica ostrearum 30CH and placebo (Calcarea carbonica ostrearum 2.9±1.1 vs placebo 1.3±1.5, difference=1.63, p<0.05). Neither weight, nor body mass index, nor abdominal circumference were different from placebo after 15 weeks of treatment. Conclusion: Calcarea carbonica ostrearum 30CH could be effective for reducing the percentage of body fat in obese adolescents. Further studies with larger sample sizes are needed to confirm these results. (AU)

Raman spectroscopy reveals variation in free OH groups and hydrogen bond strength in ultrahigh dilutions

Objective: To decipher the nature of water structure in two ultrahigh diluted (UHD) homeopathic drugs by Laser Raman Spectroscopy. Method: Two homeopathic drugs Calcarea carbonica (Calc.) and Sepia officinalis (Sep.) in 8cH, 202cH, and 1002cH and their diluent medium 90% ethanol in 8cH and 202cH were used in the present study. Laser Raman spectra of all the samples were obtained in the wave number region of 2400 – 4200 cm-1. The intensity ratio at vibration frequencies between 3200 and 3420 (R1) and that between 3620 and 3420 (R2) were calculated for each UHD of the samples. Results: The spectra show a marked difference in intensities in the stretching vibrations of CH and OH groups of all the samples. R1 values for three UHDs of Calc. and Sep. show negative and positive relationships, respectively. In the case of R2 values, the relationship in three UHDs is 8<202>1002 for Calc., and 8> 202 < 1002 for Sep. In the case of control (ethanol UHDs) both R1 and R2 show a negative relationship. Conclusion: R1 denotes a relative number of OH groups with strong and weak hydrogen bonds. R2 indicates the relative number of OH groups with broken and weak H-bonds. Therefore, the UHDs of the two drugs and the control are different from each other with respect to hydrogen bond strength of OH groups and the number of free OH groups or non-hydrogen bonded water molecules.(AU)

Raman spectroscopy reveals variation in free OH groups and hydrogen bond strength in ultrahigh dilutions

OBJECTIVE: To decipher the nature of water structure in two ultrahigh diluted (UHD) homeopathic drugs by Laser Raman Spectroscopy. METHOD: Two homeopathic drugs Calcarea carbonica (Calc.) and Sepia officinalis (Sep.) in 8cH, 202cH, and 1002cH and their diluent medium 90% ethanol in 8cH and 202cH were used in the present study. Laser Raman spectra of all the samples were obtained in the wave number region of 2400 – 4200 cm-1. The intensity ratio at vibration frequencies between 3200 and 3420 (R1) and that between 3620 and 3420 (R2) were calculated for each UHD of the samples. RESULTS: The spectra show a marked difference in intensities in the stretching vibrations of CH and OH groups of all the samples. R1 values for three UHDs of Calc. and Sep. show negative and positive relationships, respectively. In the case of R2 values, the relationship in three UHDs is 81002 for Calc., and 8> 202 < 1002 for Sep. In the case of control (ethanol UHDs) both R1 and R2 show a negative relationship. CONCLUSION: R1 denotes a relative number of OH groups with strong and weak hydrogen bonds. R2 indicates the relative number of OH groups with broken and weak H-bonds. Therefore, the UHDs of the two drugs and the control are different from each other with respect to hydrogen bond strength of OH groups and the number of free OH groups or non-hydrogen bonded water molecules.

In vitro assay on homeopathic solutions on Metarhizium anisopliae (Metsch) Sorok (Ascomycota: Clavicipitaceae) / Efeito in vitro de soluções homeopáticas sobre Metarhizium anisopliae (Metsch) Sorok (Ascomycota: Clavicipitaceae)

This study aimed to evaluate the in vitro effect of homeopathic solutions Arsenicum Album 24CH; Calcarea carbonica 30CH; Kali iodatum 100CH;Phosphorus 3CH; Silicea 30CH; Staphysagria 6, 30 and 100CH; Spodoptera frugiperda 30CH; Sulphur 100 and 200CH and Thuya occidentalis 200CH on biological parameters of the fungus Metarhizium anisopliae . The solutions were diluted in sterile distilled water (0.1%) and were sprayed on the previously inoculated fungus on PDA culture medium. Germination, colony forming units, vegetative growth, conidial production and insecticidal activity of the fungus against larvae of Diatraea saccharalis (Lepidoptera: Crambidae) were evaluated. Homeopathic solutions did not affect negatively the parameters evaluated. Thus, all treatments were considered compatible to the fungus M. anisopliae.(AU)

O presente trabalho teve por objetivo avaliar o efeito in vitro das soluções homeopáticas Arsenicum album 24CH;Calcarea carbonica 30CH; Kali iodatum100CH; Phosphorus 3CH; Silicea 30CH; Staphysagria 6, 30 e 100CH; Spodoptera frugiperda 30CH; Sulphur 100 e 200CH eThuya occidentalis 200CH sobre parâmetros biológicos do fungo Metarhizium anisopliae. As soluções medicamentosas foram diluídas em água destilada (esterilizada) (0,1%) e pulverizadas sobre o fungo previamente inoculado no meio de cultura BDA. Os parâmetros biológicos avaliados foram: germinação de conídios, unidades formadoras de colônias, crescimento vegetativo, produção de conídios e atividade inseticida contra lagartas de Diatraea saccharalis (Lepidoptera: Crambidae). As soluções não afetaram os parâmetros avaliados. Todos os tratamentos foram considerados compatíveis ao M. anisopliae .(AU)

Free water molecules and hydrogen bonding form the basis of variation in homeopathic potencies as revealed by vibrational spectroscopy

Using Fourier Transform Infrared spectroscopy (FTIR) we have demonstrated that homeopathic potencies of Natrum mur, Cantharis, Nux vomica and Sulphur show differences with respect to the number of free water molecules and strength of hydrogen bonding. The purpose of the present study is to confirm this phenomenon in three potencies of two more drugs Calcarea carb and Silicea. Design: The potencies used for each of the two drugs were 30cH, 200cH and 1000cH. The control was 90% ethanol as also the potentized drugs. The control, as well as the potencies, were diluted with distilled water to reduce the level of ethanol to 0.03 molar fraction in each of them. FTIR spectra of all the potentized drugs, control and sterile distilled water (reference water) were taken in the wave number region of 4000-2800 cm-1. The full width at half maximum (fwhm) of OH band was measured for each spectrum. The width was divided into two in the middle. The difference spectrum (absorbance of drug solution - absorbance of reference water) for each potency and the control was obtained after normalization of the spectrum at 3410 cm-1. One difference spectrum so obtained for a potency was subtracted from another to find out if there is a difference between two different potencies. Results: The half width half maximum (hwhm) in both the high and low-frequency sides of the OH band is far less narrow in potencies than in the control as compared to that in water. The difference spectra for different potencies show different levels of fall in intensity at the wave number region of dip at 3630 cm-1...

Redução e/ou negativação dos anticorpos antitireoidianos com tratamento homeopático: série de casos / Reduced and/or negative anti-thyroid antibodies after homeopathic treatment: a case series

O presente artigo descreve uma série de 9 casos de pacientes, de sexo feminino, idade de 31 a 56 anos, com diagnóstico de tireoidite autoimune, cujos títulos de anticorpos antitireoidianos diminuíram ou negativaram depois de ratamento homeopático. Além disso, em alguns casos foi possível recuperar o equilíbrio funcional da glândula. O acompanhamento foi variável, de 30 dias até 18 anos.

The present article describes a series of 9 cases corresponding to female patients, age 31 to 56 old, diagnosed with autoimmune thyroiditis, who exhibited reduced or negative anti-thyroid antibodies after homeopathic treatment. In some cases, normal function of thyroid was additionally achieved. Follow-up was variable, from 30 days to 18 years.

Tratamento homeopático na erupção dentária decídua

Objetivos: Realizar uma breve revisão da literatura a respeito da sintomatologia associada à erupção dental, a fim de chamar a atenção dos profissionais da saúde que prestam atendimento a crianças para o desenvolvimento dos trabalhos de pesquisa nesta área. Fonte pesquisadas: livre escolha de artigos pertinentes da literatura relacionados ao processo de erupção dental e sintomatologias associadas. Síntese dos dados: é comum que os pais e profissionais da saúde relatem que o processo de erupção dos dentes decíduos pode estar associado a alterações locais e sistêmicas. Embora as alterações locais como edema, eritema e prurido gengival estejam diretametne ligados à erupção dental, outros fatores sistêmicos de ordem geral, como febre, irritabilidade, perda do sono e apetite e até mesmo convulsões não estão claramente associados. Realizada a descrição da matéria médica homeopática dos principais medicamentos utilizados, a fim de minimizar os sintomas descritos acima. Conclusão: a erupção dos dentes decíduos e os possíveis efeitos do processo de erupção dental na saúde infantil tá muitos anos e crenças tradicionais sobre o assunto ainda não foram inteiramente embasadas por achados científicos. (AU)

Objectives: to carry out a brief review of the literature about the symptomatology associated to dental eruption in order to call the attention of health professionals assisting children to the development of research works in this field. Researched sources: free choice of pertinent literature articles related to the dental eruption process and associated symptomatologies. Data syntheses: it is common that parents and health professionals report that the deciduos teeth eruption process may be associated to local and systemic alterations. Although local alterations such as edema, erytema and gum pruritus are directly relatead to dental eruption, other general systemic factors such as fever, irritability, sleeplessness and lack of appetite, and even seizures, are not clearly associated to it. The knowledge of classic works described in the literature consulted in this review is important t guide health professionals to develop new researches in this field. It was done a description of main homeopathic medicines to minimize all this symptoms. Conclusion: deciduos teeth eruption and the possible effects of the dental eruption process in the child’s health have been debated for many years, and tradicional beliefs about the matter were still not entirely based on scientific findings. (AU)

Redução e/ou negativação dos anticorpos antitireoidianos com tratamento homeopático: série de casos / Reduced and/or negative anti-thyroid antibodies after homeopathic treatment: a case series

O presente artigo descreve uma série de 9 casos de pacientes, de sexo feminino, idade de 31 a 56 anos, com diagnóstico de tireoidite autoimune, cujos títulos de anticorpos antitireoidianos diminuíram ou negativaram depois de ratamento homeopático. Além disso, em alguns casos foi possível recuperar o equilíbrio funcional da glândula. O acompanhamento foi variável, de 30 dias até 18 anos. (AU)

The present article describes a series of 9 cases corresponding to female patients, age 31 to 56 old, diagnosed with autoimmune thyroiditis, who exhibited reduced or negative anti-thyroid antibodies after homeopathic treatment. In some cases, normal function of thyroid was additionally achieved. Follow-up was variable, from 30 days to 18 years. (AU)

Free water molecules and hydrogen bonding form the basis of variation in homeopathic potencies as revealed by vibrational spectroscopy

Objective: Using Fourier Transform Infrared spectroscopy (FTIR) we have demonstrated that homeopathic potencies of Natrum mur, Cantharis, Nux vomica and Sulphur show differences with respect to the number of free water molecules and strength of hydrogen bonding. The purpose of the present study is to confirm this phenomenon in three potencies of two more drugs Calcarea carb and Silicea. Design: The potencies used for each of the two drugs were 30cH, 200cH and 1000cH. The control was 90% ethanol as also the potentized drugs. The control, as well as the potencies, were diluted with distilled water to reduce the level of ethanol to 0.03 molar fraction in each of them. FTIR spectra of all the potentized drugs, control and sterile distilled water (reference water) were taken in the wave number region of 4000-2800 cm-1. The full width at half maximum (fwhm) of OH band was measured for each spectrum. The width was divided into two in the middle. The difference spectrum (absorbance of drug solution - absorbance of reference water) for each potency and the control was obtained after normalization of the spectrum at 3410 cm-1. One difference spectrum so obtained for a potency was subtracted from another to find out if there is a difference between two different potencies. Results: The half width half maximum (hwhm) in both the high and low-frequency sides of the OH band is far less narrow in potencies than in the control as compared to that in water. The difference spectra for different potencies show different levels of fall in intensity at the wave number region of dip at 3630 cm-1. The level of dip at 3630 cm-1 and subsequent rise in intensity in the lower frequency region represent the quantity of free water molecules and strong alcoholic OH bond around 3250 cm-1, respectively. The results of subtraction between two different potencies are not zero but have marked positive or negative values. Conclusion (i) Potencies have stronger intermolecular interactions and a higher number of chemical environments than the control, as revealed by the data on hwhm. (ii) The three potencies of each of the two drugs show distinct variation in the number of free water molecules and strength of hydrogen bonding. (iii) There exists both inter-drug and inter-potency variation as revealed by the difference spectra and results of subtraction between two difference spectra.(AU)

Tratamiento homeopático para el vitiligo: un estudio piloto abierto observacional / Homoeopathic treatment of vitiligo: an open observational pilot study

Antecedentes: El vitiligo es un trastorno común de hipopigmentación que genera un impacto psicológico muy importante. En una clínica de atención ambulatoria en Bengala Occidental, India, se realizó una evaluación del tratamiento homeopático en individuos con vitiligo. Métodos: Se reclutaron 30 pacientes (edad media de 27 años; 57% femeninos) para un estudio piloto prospectivo abierto, y se manejaron con tratamiento homeopático individualizado durante seis meses. Se evaluó La eficacia del tratamiento a los tres y seis meses, utilizando el Índice de Puntuación del Área con Vitiligo (Vitiligo Area Scoring Index, VASI), la escala de la Comisión Europea de Vitiligo (Vitiligo European Task Force, VETF) y el Índice de Calidad de Vida en Dermatología (Dermatological Life Quality Index, DLQI), los cuales validaron el índice de mejoría tomando en cuenta el área, la intensidad, la extensión de La despigmentación de las lesiones de vitiligo y la calidad de vida (QoL). Resultados: Un total de 27 pacientes completaron el estudio; tres desertaron. Después de seis meses de tratamiento, la medida media de VASI mejoró significativamente en 0.1 unidades (p=0.003), de 0.8 (0.5, 1.5) a 0.7 (0.3, 0.8) en una escala de 0 (sin despigmentación) y 100 (completamente despigmentada). Del mismo modo, la media del VETF mejoró su puntuación por 2 unidades (p=0.0001), de 1 (0.1) a -1 (-1.0), y el marcador de estadificación varió de 1 (1.2) a 1 (0.1), p=0.002. La media de La puntuación total de DLQI disminuyó de 21 (17, 22) a 13.6 (10, 17), con variación de 7.4 (p=0.0001); dicha variación también fue corroborada por los componentes del DLQI. Conclusiones: El tratamiento homeopático individualizado se asoció con una mejoría significativa de las puntuaciones en VASI, VETF y DLQI. La premisa de que los efectos observados se deben a placebo se debe aclarar en futuros ensayos clínicos aleatorios doble ciego, precedidos por estudios de viabilidad. (AU)

Background: Vitiligo is a common hypopigmentation disorder with significant psychological impact. An evaluation of homeopathic treatment was performed in individuals with vitiligo in a hospital outpatient clinic in West Bengal, India. Methods: 30 participants (median age 27 years old, 57% female) were recruitedfor a prospective open-label pilot study and treated with individualized homeopathic medicines for six months. Efficacy was assessed after three months and six months using Vitiligo Area Scoring Index (VASI) score, Vitiligo European Task Force (VETF)score, and Dermatological Life Quality Index (DLQI) score, which are validatedoutcome measures evaluating the area, intensity, spread of depigmentation ofvitiligo lesions, and quality of life (QoL). Results: A total of 27 participants completed the trial; 3 dropped out. After 6 months of treatment, the median VASI total score improved significantly by 0.1 units (p=0.003), from 0.8 (0.5, 1.5) to 0.7 (0.3, 0.8) on a scale from 0 (no depigmentation) to 100 (completely depigmented). Similarly, the VETF median score improved by 2 units (p=0.0001) from 1 (0, 1) to -1 (-1, 0) and the staging score changed from 1 (1, 2) to 1 (0, 1), p=0.002. The total DLQI median score exhibited significant reduction from 21 (17, 22) to 13.6 (10, 17), change 7.4 (p=0.0001), as also did its components. Conclusions: Individualized homeopathictreatment associated with significant improvement of VASI, VETF and DLQI scores. The extent to which the observed effects were due to placebo needs clarificationin future randomized double-blind clinical studies preceded by feasibility studies. (AU)

Tratamiento homeopático para el vitiligo: un estudio piloto abierto observacional / Homoeopathic treatment of vitiligo: an open observational pilot study

Antecedentes: El vitiligo es un trastorno común de hipopigmentación que genera un impacto psicológico muy importante. En una clínica de atención ambulatoria en Bengala Occidental, India, se realizó una evaluación del tratamiento homeopático en individuos con vitiligo. Métodos: Se reclutaron 30 pacientes (edad media de 27 años; 57% femeninos) para un estudio piloto prospectivo abierto, y se manejaron con tratamiento homeopático individualizado durante seis meses. Se evaluó La eficacia del tratamiento a los tres y seis meses, utilizando el Índice de Puntuación del Área con Vitiligo (Vitiligo Area Scoring Index, VASI), la escala de la Comisión Europea de Vitiligo (Vitiligo European Task Force, VETF) y el Índice de Calidad de Vida en Dermatología (Dermatological Life Quality Index, DLQI), los cuales validaron el índice de mejoría tomando en cuenta el área, la intensidad, la extensión de La despigmentación de las lesiones de vitiligo y la calidad de vida (QoL). Resultados: Un total de 27 pacientes completaron el estudio; tres desertaron. Después de seis meses de tratamiento, la medida media de VASI mejoró significativamente en 0.1 unidades (p=0.003), de 0.8 (0.5, 1.5) a 0.7 (0.3, 0.8) en una escala de 0 (sin despigmentación) y 100 (completamente despigmentada). Del mismo modo, la media del VETF mejoró su puntuación por 2 unidades (p=0.0001), de 1 (0.1) a -1 (-1.0), y el marcador de estadificación varió de 1 (1.2) a 1 (0.1), p=0.002. La media de La puntuación total de DLQI disminuyó de 21 (17, 22) a 13.6 (10, 17), con variación de 7.4 (p=0.0001); dicha variación también fue corroborada por los componentes del DLQI. Conclusiones: El tratamiento homeopático individualizado se asoció con una mejoría significativa de las puntuaciones en VASI, VETF y DLQI. La premisa de que los efectos observados se deben a placebo se debe aclarar en futuros ensayos clínicos aleatorios doble ciego, precedidos por estudios de viabilidad.

Background: Vitiligo is a common hypopigmentation disorder with significant psychological impact. An evaluation of homeopathic treatment was performed in individuals with vitiligo in a hospital outpatient clinic in West Bengal, India. Methods: 30 participants (median age 27 years old, 57% female) were recruitedfor a prospective open-label pilot study and treated with individualized homeopathic medicines for six months. Efficacy was assessed after three months and six months using Vitiligo Area Scoring Index (VASI) score, Vitiligo European Task Force (VETF)score, and Dermatological Life Quality Index (DLQI) score, which are validatedoutcome measures evaluating the area, intensity, spread of depigmentation ofvitiligo lesions, and quality of life (QoL). Results: A total of 27 participants completed the trial; 3 dropped out. After 6 months of treatment, the median VASI total score improved significantly by 0.1 units (p=0.003), from 0.8 (0.5, 1.5) to 0.7 (0.3, 0.8) on a scale from 0 (no depigmentation) to 100 (completely depigmented). Similarly, the VETF median score improved by 2 units (p=0.0001) from 1 (0, 1) to -1 (-1, 0) and the staging score changed from 1 (1, 2) to 1 (0, 1), p=0.002. The total DLQI median score exhibited significant reduction from 21 (17, 22) to 13.6 (10, 17), change 7.4 (p=0.0001), as also did its components. Conclusions: Individualized homeopathictreatment associated with significant improvement of VASI, VETF and DLQI scores. The extent to which the observed effects were due to placebo needs clarificationin future randomized double-blind clinical studies preceded by feasibility studies.

Tratamento para Diabetes melito tipo 1 canina através de medicamentos homeopáticos / Treatment for Diabetes mellitus type 1 canine with homeopathic medicine

A diabetes mellitus é uma doença crônica sistêmica decorrente de uma deficiência relativa ou absoluta de insulina. É uma das endocrinopatias mais comuns nos cães e pode ser fatal se não for diagnosticada e tratada adequadamente. É um conjunto de manifestações clínicas que afeta sereshumanos e animais: o fenômeno predisponente é o metabolismo anormal ou inadequado da glicose, em decorrência de uma deficiência relativa ou absoluta de insulina. É uma síndrome que compromete o metabolismo dos carboidratos, das gorduras, e das proteínas, devido a, deficiência parcial ou absoluta da secreção de insulina dada pelas células beta, produzidas pelas ilhotas de Langerhans, no pâncreas ou por redução da sensibilidade dos tecidos à insulina. O objetivo deste trabalho é revisar a literatura, os sinais clínicos, sintomas e complicações da diabetes mellitus tipo I canina e seu tratamento tradicional, e discutir a utilização de medicamentos homeopáticos. (AU)

Homoeopathic treatment of vitiligo: an open observational pilot study

Background: Vitiligo is a common hypopigmentation disorder with significant psychological impact. An evaluation of homeopathic treatment was performed in individuals with vitiligo in a hospital outpatient clinic in West Bengal, India. Methods: Thirty participants (median age 27 years old, 57% female) were recruited for a prospective open-label pilot study and treated with individualized homeopathic medicines for 6 months. Efficacy was assessed after 3 months and 6 months using Vitiligo Area Scoring Index (VASI) score, Vitiligo European Task Force (VETF) score, and Dermatological Life Quality Index (DLQI) score, which are validated outcome measures evaluating the area, intensity, spread of depigmentation of vitiligo lesions, and quality of life (QoL). Results: A total of 27 participants completed the trial; 3 dropped out. After 6 months of treatment, the median VASI total score improved significantly by 0.1 units (p=0.003), from 0.8 (0.5, 1.5) to 0.7 (0.3, 0.8) on a scale from 0 (no depigmentation) to 100 (completely depigmented). Similarly, the VETF median score improved by 2 units (p=0.0001) from 1 (0, 1) to –1 (–1, 0) and the staging score changed from 1 (1, 2) to 1 (0, 1), p=0.002. The total DLQI median score exhibited significant reduction from 21 (17, 22) to 13.6 (10, 17), change 7.4 (p=0.0001), as also did its components. Conclusions: Individualized homeopathic treatment associated with significant improvement of VASI, VETF and DLQI scores. The extent to which the observed effects were due to placebo needs clarification in future randomized double-blind clinical studies preceded by feasibility studies. (AU)

Introdução: Vitiligo é uma desordem de hipopigmentação de ocorrência comum, com impacto psicológico significativo. Foi avaliado o tratamento homeopático de indivíduos com vitiligo no ambulatório de um hospital em Bengala Ocidental, Índia. Métodos: Trinta participantes (idade mediana 27 anos, sendo 57% do gênero feminino) foram recrutados para o presente estudo piloto prospectivo aberto e tratados com medicamentos homeopáticos individualizados por 6 meses. A eficácia do tratamento foi avaliada aos 3 e 6 meses mediante Vitiligo Area Scoring Index (VASI) score, Vitiligo European Task Force (VETF), e Dermatological Life Quality Index (DLQI), que são medidas validadas de desfecho correspondendo à área, intensidade e disseminação da depigmentação causada por vitiligo, assim como a qualidade de vida (QV). Resultados: Um total de 27 participantes completou o estudo, sendo que 3 abandonaram. Depois de 6 meses de tratamento, a mediana do escore total do VASI apresentou melhora significativa de 0,1 unidade (p=0,003) passando de 0,8 (0,5, 1,5) para 0,7 (0,3, 0,8), numa escala de 0 (sem depigmentação) a 100 (depigmentação completa). De modo similar, a mediana do escore VETF de disseminação melhorou em 2 unidades (p=0,0001) de 1 (0, 1) a –1 (–1, 0), e o escore de estadiamento variou de 1 (1, 2) para 1 (0, 1), p=0,002. O escore total mediano de DLQI diminuiu de 21 (17, 22) a 13,6 (10, 17), com uma variação de 7,4 (p=0,0001); variação também foi constatada nos componentes de DLQI. Conclusões: O tratamento homeopático individualizado se associou com melhora significativa nos escores de VASI, VETF e DLQI. A parte dos efeitos possivelmente devida a efeito placebo precisa ser determinada em futuros estudos clínicos randomizados e duplo cego, após a realização de estudos de factibilidade. (AU)

Homoeopathic treatment of vitiligo: an open observational pilot study

Background: Vitiligo is a common hypopigmentation disorder with significant psychological impact. An evaluation of homeopathic treatment was performed in individuals with vitiligo in a hospital outpatient clinic in West Bengal, India. Methods: Thirty participants (median age 27 years old, 57% female) were recruited for a prospective open-label pilot study and treated with individualized homeopathic medicines for 6 months. Efficacy was assessed after 3 months and 6 months using Vitiligo Area Scoring Index (VASI) score, Vitiligo European Task Force (VETF) score, and Dermatological Life Quality Index (DLQI) score, which are validated outcome measures evaluating the area, intensity, spread of depigmentation of vitiligo lesions, and quality of life (QoL). Results: A total of 27 participants completed the trial; 3 dropped out. After 6 months of treatment, the median VASI total score improved significantly by 0.1 units (p=0.003), from 0.8 (0.5, 1.5) to 0.7 (0.3, 0.8) on a scale from 0 (no depigmentation) to 100 (completely depigmented). Similarly, the VETF median score improved by 2 units (p=0.0001) from 1 (0, 1) to –1 (–1, 0) and the staging score changed from 1 (1, 2) to 1 (0, 1), p=0.002. The total DLQI median score exhibited significant reduction from 21 (17, 22) to 13.6 (10, 17), change 7.4 (p=0.0001), as also did its components. Conclusions: Individualized homeopathic treatment associated with significant improvement of VASI, VETF and DLQI scores. The extent to which the observed effects were due to placebo needs clarification in future randomized double-blind clinical studies preceded by feasibility studies.

Introdução: Vitiligo é uma desordem de hipopigmentação de ocorrência comum, com impacto psicológico significativo. Foi avaliado o tratamento homeopático de indivíduos com vitiligo no ambulatório de um hospital em Bengala Ocidental, Índia. Métodos: Trinta participantes (idade mediana 27 anos, sendo 57% do gênero feminino) foram recrutados para o presente estudo piloto prospectivo aberto e tratados com medicamentos homeopáticos individualizados por 6 meses. A eficácia do tratamento foi avaliada aos 3 e 6 meses mediante Vitiligo Area Scoring Index (VASI) score, Vitiligo European Task Force (VETF), e Dermatological Life Quality Index (DLQI), que são medidas validadas de desfecho correspondendo à área, intensidade e disseminação da depigmentação causada por vitiligo, assim como a qualidade de vida (QV). Resultados: Um total de 27 participantes completou o estudo, sendo que 3 abandonaram. Depois de 6 meses de tratamento, a mediana do escore total do VASI apresentou melhora significativa de 0,1 unidade (p=0,003) passando de 0,8 (0,5, 1,5) para 0,7 (0,3, 0,8), numa escala de 0 (sem depigmentação) a 100 (depigmentação completa). De modo similar, a mediana do escore VETF de disseminação melhorou em 2 unidades (p=0,0001) de 1 (0, 1) a –1 (–1, 0), e o escore de estadiamento variou de 1 (1, 2) para 1 (0, 1), p=0,002. O escore total mediano de DLQI diminuiu de 21 (17, 22) a 13,6 (10, 17), com uma variação de 7,4 (p=0,0001); variação também foi constatada nos componentes de DLQI. Conclusões: O tratamento homeopático individualizado se associou com melhora significativa nos escores de VASI, VETF e DLQI. A parte dos efeitos possivelmente devida a efeito placebo precisa ser determinada em futuros estudos clínicos randomizados e duplo cego, após a realização de estudos de factibilidade.

Acercamiento homeopático a la conjuntivitis alérgica / Homeopathic Approach to allergic conjunctivitis

La conjuntivitis alérgica (CA) es un proceso inflamatorio de la conjuntiva ocular, generado por una alteración de la respuesta inmune desencadenada por la presencia de antígenos ambientales. Aunque se considera como una hipersensibilidad de tipo I, aún se tienen varias interrogantes sobre su desarrollo fisiopatológico. Se le reconocen dos fases: la primera, o de sensibilización, donde se lleva a cabo el primer contacto con el antígeno que, a su vez, desencadena una serie de mecanismos que conducen a la producción de IgE específica, la cual se fija a su receptor en las células cebadas conjuntivales. La segunda fase, también llamada efectora, se presenta cuando aparece un segundo encuentro con el antígeno desencadenante, el cual se fija a las IgE en la superficie de las células cebadas y genera una serie de eventos fisiopatológicos que producen las manifestaciones clínicas de la CA. En este articulo se realiza un análisis profundo de los mecanismos que generan la conjuntivitis alérgica y de los medicamentos homeopáticos que más frecuentemente se adaptan a los síntomas de dicha enfermedad, como es el caso de la Calcarea carbónica, que tiende a ser uno de los más importantes cuando el proceso alérgico se manifiesta no sólo en los ojos, sino en la piel; la Belladonna atropa, indicada en conjuntivitis con dilatación pupilar acompañada de enrojecimiento conjuntival intenso, y la Euphrasía ofticinalis, uno de los medicamentos más organotrópicos para la conjuntiva.